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Side Effect

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Since COVID-19 vaccines are new, some people have asked about their effects on those who take them. Short-term side effects (i.e., those that happen in the days after a vaccine has been given) are readily apparent because of clinical trial reports and personal experiences, but people also wonder about possible long-term effects of these vaccines. To answer this question, scientists study the available evidence, and while the rules of science do not allow scientists to say that long-term effects can never happen, the evidence is strong that these vaccines will not cause long-term harm.

These experiences demonstrate two important findings. First, when these events occurred, the onset was within eight weeks of receipt of the vaccine. Second, in all of these cases, except narcolepsy following H1N1 vaccine, the side effect of the vaccine was something that could be caused by the infection, meaning that getting infected with the virus also carried a risk of experiencing these outcomes. In the narcolepsy experience, the cause was determined to be related to the adjuvant used in that preparation of vaccine.

Even with this history in mind, some reasonably wonder about the COVID-19 vaccines because they have not previously been approved for use in people. Now that millions of doses have been administered, we have learned about a few rare but severe side effects. They all occur shortly after vaccination:

In each of these cases, the side effect occurred within a few days up to a few weeks of vaccination, but all occurred well before two months after vaccination. Likewise, COVID-19 infection also causes myocarditis and GBS and is associated with a variety of blood clotting issues, and the risk of experiencing them is greater following infection than following vaccination.

You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. You should not use it to replace any relationship with a physician or other qualified healthcare professional. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel.

Treat dryness: Once you stop taking the medication, dryness will clear. Until then, you can get relief with moisturizer, lip balm, and artificial tears. For nosebleeds, apply petroleum jelly just inside your nose. This helps keep the tissue moist, which can prevent nosebleeds.

To find out whether this medication can cause IBD, researchers continue to study this possible side effect. This research takes time. Researchers have to account for many considerations. For example, it's possible that the genes which increase your risk of having severe acne also increase your risk of developing IBD.

Here is a list of symptoms, or side effects, that some people experience when they start taking HIV medications, along with some suggestions for what you can do at home to manage them. Many side effects can be improved through diet, exercise, and quality sleep; most side effects get better after about a week's time. Because what seems like a side effect may actually be a sign of a more serious condition, such as a drug toxicity or an infection, be sure to discuss any changes in your health with your medical provider.

A side effect (also known as adverse reaction) is a harmful and unintended response to a health product. Health products include prescription and non-prescription medications; natural health products; biologics (includes biotechnology products, vaccines, fractionated blood products, human blood and blood components, as well as human cells, tissues and organs) radiopharmaceuticals; and disinfectants and sanitizers with disinfectant claims. This includes any undesirable patient effect suspected to be associated with health product use. An unintended effect, health product abuse, overdose, interaction (including drug-drug and drug-food interactions) and unusual lack of therapeutic efficacy are all considered to be reportable side effects.

A serious side effect is one that requires in-patient hospitalization or prolongation of existing hospitalization, causes congenital malformation, results in persistent or significant disability or incapacity, is life-threatening or results in death. Side effects that result in significant medical intervention to prevent one of these listed outcomes are also considered to be serious.

In the context of Health Canada's side effect reporting program (the Canada Vigilance Program), personal information is collected pursuant to section 4 of the Department of Health Act, for the purpose of monitoring licensed products, detecting potential emerging safety issues and trends, mitigating the risks and improving the safe use and efficacy of the health products. Information related to the identity of the patient and/or reporter will be protected as personal information under the Privacy Act, and in the case of an access to information request, under the Access to Information Act. Suspected health product side effect-related information that is voluntarily submitted to Health Canada is maintained in a secure computerized database. The program endeavours to use and disclose only de-identified information but may use and disclose personal information that is not de-identified as permitted under the Privacy Act. For further details regarding the personal information collected under this program, visit the Personal Information Bank; Health Canada; Health Products and Food Branch; Branch Incident Reporting System; PIB#PPU 088. Every Canadian individual has the right to access their own personal information and is entitled to request correction to ensure accuracy of their information. If you wish to exercise this right, contact the Treasury Board of Canada Secretariat.

In partnership with leading melanoma oncology experts, AIM has developed comprehensive and up-to-date information on the side effects of commonly used melanoma treatments currently approved by the U.S. Food and Drug Administration.

Please click on the drug(s) you are interested in for a downloadable document that will help you recognize and manage your side effects. We encourage you to bring the document to your next healthcare appointment to discuss it with your provider.

Immunotherapy side effects may be different from those associated with conventional cancer treatments because they result from an overstimulated or misdirected immune response rather than the direct effect of a chemical or radiological therapy on cancer and healthy tissues. Immune-related side effects can, in principle, affect any tissue or organ in the body. These side effects can range from mild to moderate or severe and can become potentially life-threatening under certain circumstances.

Fortunately, in most cases potential immunotherapy-related side effects can be managed safely with immunosuppressive drugs such as steroids as long as the potential side effects are recognized and addressed early.

While severe side effects are uncommon, when they do occur they may be life-threatening and require immediate medical intervention. Most of these severe side effects are linked to inflammation, and may include but are not limited to:

The intended purpose of chemotherapy is to target growing cancer cells, so it may cause collateral damage to other growing normal cells in your body, such as hair follicles, taste buds, or the lining of the stomach or gut. Common side effects of chemotherapy may include but are not limited to: diarrhea, fatigue, hair loss, nausea, and skin rash. Learn more about the differences between immunotherapy and chemotherapy.

Radiation uses radioactive particles to destroy cancer cells in a localized area, so it may damage other healthy cells in that area. Side effects may often be associated with the area of treatment, and may include difficulty breathing when aimed at the chest, or nausea when aimed at the stomach. Skin problems and fatigue are common.

The goal of surgery is to remove the cancerous tumor or tissue and varies according to the type of surgery performed. Common side effects may include but are not limited to: fatigue, numbness, pain, risk of infection, and swelling.

Some of the most common side effects associated with immunotherapy treatment may include but are not limited to: chills, constipation, coughing, decreased appetite, diarrhea, fatigue, fever and flu-like symptoms, headache, infusion-related reaction or injection site pain, itching, localized rashes and/or blisters, nausea, rash, shortness of breath, vomiting, and weight loss.

Depending on the treatment, immunotherapy side effects can be treated in a number of ways. For example, patients may be taken off treatment, either temporarily or permanently, in order to allow the immune activity to quiet down. Additionally, especially with checkpoint inhibitor immunotherapies, patients may receive steroids or immunosuppressive antibodies as a more active measure in order to dampen immune activity and minimize potential damage from any further autoimmune reactions.

In the case of the cytokine release syndrome (or cytokine storm), among potential CAR T cell therapy side effects, doctors may administer drugs to block the activity of certain cytokine signaling pathways, such as interleukin-1 (IL-1) or interleukin-6 (IL-6).

More work still needs to be done to definitively answer this important question, although some recent studies have found that patients who experience low-grade side effects after immunotherapy may be more likely to have better outcomes.

There are a number of ways for doctors to monitor side effects. Patients, however, will often be aware of changes in their own bodies before their doctors have a chance to monitor and detect any side effects. It therefore is important for patients to report any adverse changes in their health or overall well-being to their healthcare team as soon as they are aware of them. 59ce067264


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